The future of teratology research is in vitro

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The future of teratology research is in vitro

Birth defects induced by maternal exposure to exogenous agents during pregnancy are preventable, if the agents themselves can be identified and avoided. Billions of dollars and manhours have been dedicated to animal-based discovery and characterisation methods over decades. We show here, via a comprehensive systematic review and analysis of this data, that these methods constitute questionable ...

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The purpose of this conference was to reevaluate the need for and use of in vitro teratology assays; to examine the validation process for in vitro tests; and to discuss progress in the validation of in vitro teratology screens. Participants enthusiastically supported further development of short-term in vivo and in vitro systems both as prescreens for developmental toxicity and as experimental...

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ژورنال

عنوان ژورنال: Biogenic Amines

سال: 2005

ISSN: 0168-8561,1569-3910

DOI: 10.1163/1569391053722755